Chunk #15 — Late-onset Alzheimer’s disease
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Sortilin-related receptor (SORL1) on chromosome 11q23-24 may be involved in Abeta recycling. The under-expression of SORL1 can increase Abeta generation. Intronic polymorphisms, located near the 3′ end of the SORL1 coding region, might be associated with AD.159,160