Research also has found compromised NAA/tCr levels in patients with cerebellar degeneration (Tedeschi et al. 1996; Terakawa et al. 1999). Two MRS case studies of MBD showed reduced NAA/tCr and elevated Cho/tCr in corpus callosum splenium (Gambini et al. 2003; Tuntiyatorn and Laothamatas 2008), findings consistent with demyelination (elevated Cho) and axonal injury (reduced NAA).
