In the only report of MRS conducted in a case of alcoholism-associated CPM, elevated Cho/tCr was found and interpreted as reflecting edema or demyelination in a 53-year-old man with gait disturbances and hearing loss (Nomoto et al. 2004). In 12 patients with chronic hyponatremia (nonalcohol etiology), MRS showed reduced Cho and mI relative to unaffected study participants, reflecting osmolyte disturbances (Videen et al. 1995).
