In addition, genetic studies showed that Ucn 1 levels in the pIIIu were higher in 2 out of 5 rat lines selectively bred for high alcohol intake compared to lines showing low alcohol intake. A meta-analysis across five pairs of selectively-bred rat lines showed that alcohol-preferring lines had more Ucn 1 fibers in the lateral septum when compared to non-preferring lines (Turek et al., 2005).
