Evidence implicating Ucn 1 in alcohol self-administration in rats also exists. For example, it has been shown that ethanol dose-dependently increased c-Fos expression in the in pIIIu in genetically selected alcohol preferring AA (Alko alcohol) rats and in beer drinking Sprague-Dawley rats. No effects of saccharin on c-Fos expression were found (Weitemier et al., 2001)
