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Chunk #19 — Materials and Methods — Statistical Analysis

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Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents.
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moderators (i.e., deviant peer affiliation, parental monitoring), and the candidate gene × moderator interactions. Continuous independent variables (deviant peer affiliation, parental monitoring) were centered prior to being entered into the models. Potential confounding effects of sex and age were controlled by entering these variables as covariates. The most parsimonious model was identified using the backward elimination method (α = 0.10).The Bonferroni method was used to control for inflation of Type I error by adjusting the threshold of significance (α = 0.05) for each hypothesized gene × moderator interaction (Dar et al., 1994),yielding a modified threshold of significance (α = 0.025).