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Chunk #55 — Methods — Meta-analyses and independent variants.

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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.
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We determined credible variants among the independent variants by merging risk variants within 1Mb of the lead variant and fine-mapped the resulting region with 95% credible sets using FINEMAP.90 Posterior inclusion probability ranges from 0 to 1 with values closer to 1 indicating greater causal probability. We implicated a putative causal variant if it accounted for > 50% of the posterior probability in the 95% credible set.