To identify TUD risk loci and lead SNPs, we performed LD clumping in FUMA41 using a range of 3 Mb, r2 >0.1, and the respective ancestry 1000 Genome reference panel.77 Genomic risk loci that were located <1Mb apart were incorporated into a single locus. For loci that harbored multiple variants, we used COJO in GCTA89 to define independent variants by conditioning them on the most significant variant within each locus. Following conditioning, significant variants (p<5.00E-08) were considered independent.
