We conducted five meta-analyses of TUD GWAS summary statistics across the following datasets: 1) within-ancestry meta-analysis for EUR samples in BioVU, MGBB, PMBB, MVP, and an additional meta-analysis including UKBB, 2) within-ancestry meta-analysis for AA in MVP and Penn, and 3) multi-ancestry meta-analysis across EUR (BioVU, MGBB, PMBB, MVP), AA (PMBB, MVP), and HA (MVP) datasets, and an additional meta-analysis including UKBB. Inflation of test statistics due to polygenicity or cryptic relatedness was assessed using the LDSC attenuation ratio [(LDSC intercept - 1)/(mean of association chi-square statistics - 1)]. Resulting genome-wide significant (GWS) loci were defined as those with p<5.00E-08 with LD r2>0.1, within a 1MB window, based on the structure of the Haplotype Reference Consortium (HRC) multi-ancestry reference panel for the multi-ancestry meta-analysis, or the HRC ancestry-appropriate reference panel otherwise. GWS loci were examined for heterogeneity across cohorts via the I2inconsistency metric.
