Each of the syndromes is characterized by extensive structural deviations from a healthy brain; the morphological changes, however, are not exclusively linked to a diagnosable neurological disorder. These changes are also, though to a lesser extent, consistently described in uncomplicated alcoholism. For example, volume deficits in frontal cortex, thalamus, and mammillary bodies of uncomplicated alcoholics compared to healthy controls have been reported (Sullivan et al., 2003; Sullivan et al., 1999; van Holst, de Ruiter, van den Brink, Veltman, & Goudriaan, 2012; Zahr & Pfefferbaum, 2017). Thinning of the corpus callosum (main characteristics of MBD) (Estruch et al., 1997; Pfefferbaum, Lim, Desmond, & Sullivan, 1996) and volume reduction of the pons are also observed in uncomplicated alcoholics compared to healthy controls (Pfefferbaum, Rosenbloom, Serventi, & Sullivan, 2002; Sullivan et al., 2003). Basal ganglia structures are affected (Durazzo et al., 2011; Makris et al., 2008) and include the caudate (Boutte et al., 2012), putamen (Jernigan et al., 1991), amygdala (Fein et al., 2006), and nucleus accumbens (Sullivan, Deshmukh, De Rosa, Rosenbloom, & Pfefferbaum, 2005). Such changes to nodes of the basal ganglia
