Marchiafava-Bigami Disease (MBD) is marked by a mildly impaired mental status (e.g. confusion) and sometimes dysarthria (i.e., impairment of the speech)(H. Lee, Holburn, & Price, 2003) or ataxia (i.e., loss of control over bodily movement)(Arbelaez, Pajon, & Castillo, 2003). Although this disease is poorly understood, there exist indications that it may be linked to chronic alcohol consumption and nutritional deficiencies. MBD is traditionally characterized by demyelination and necrosis of the corpus callosum (Figure 1E) (Hillbom et al., 2014).
