There were significant associations between daily life events and alcohol dependence (Table 3, Model I). Additional daily hassles were associated with a strong increase in the odds of alcohol dependence (OR = 2.45, p <0.001). Two-way GxE interactions between daily hassles and genotype (not shown) and daily uplifts and genotype were not statistically significant (Model II). The three-way interaction between gender, daily hassles, and genotype was not statistically significant (not shown). However, the addition of a three-way interaction term in Model III reflected a statistically significant moderation of risk for alcohol dependence by higher levels of daily uplifts only for men who were high risk at GABRA2 (p < 0.05). Specifically, for men with the high-risk genotype, additional positive daily experiences were associated with a significant decrease in risk for alcohol dependence (OR = 0.51, p < 0.05). However, for men with the low-risk genotype (OR = 0.94) and women with both the high-(OR = 1.02) and low-risk (OR = 0.90) genotypes, uplifts had no significant relationship to the estimated odds of alcohol dependence.
