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Chunk #50 — Results — Attenuation in power and R2 due to imperfect CGR

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Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies.
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Regarding attenuation, we observed a substantial spread in the predicted number of hits and PGS R2 when assuming either a CGR equal to one, or a CGR in accordance with empirical estimates, with traits with lower CGR suffering from stronger attenuation in power and predictive accuracy. In line with theory, R2 falls approximately quadratically with CGR. For instance, for self-rated health, the estimated CGR of about 0.5, would yield a PGS that retains approximately 0.52 = 25% of the R2 it would have had under a CGR of one. Hence the approximated attenuation is 75%. This approximation is corroborated by the theoretical relative attenuation of 78%.