Chunk #51 — Results — Attenuation in power and R2 due to imperfect CGR

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Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies.

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Given our CGR estimates, the theoretical relative loss in PGS R2 is 6% for height, 14% for BMI, 36% for EduYears, and 78% for self-rated health, when compared to the R2 of PGSs under perfect CGRs (Table 2). These losses in R2 are unlikely to be reduced by larger sample sizes and denser genotyping.