Somewhat contrary to expectation, the number of hits seems to respond even more strongly to CGR than PGS R2. However, since in each study under consideration the average power per associated SNP is quite small, a small decrease in power per SNP in absolute terms can constitute a substantial decrease in relative terms. For instance, when one has 2% power per truly associated SNP, an absolute decrease of 1%—leaving 1% power—constitutes a relative decrease of 50% of power per causal SNP, and thereby a 50% decrease in the expected number of hits. This strong response shows, for example, in the case of EduYears, where the expected number of hits drop by about 37% when going from a CGR of one down to a CGR of 0.783.
