P values quantifying the degree of association of genes and gene sets with BD were calculated using MAGMA v1.0837, implemented in FUMA v1.3.6a64,108. Gene-based tests were performed for 19,576 genes (Bonferroni-corrected P-value threshold = 2.55 × 10−6). A total of 11,858 curated gene sets including at least 10 genes from MSigDB V7.0 were tested for association with BD (Bonferroni-corrected P-value threshold = 4.22 × 10−6). Competitive gene-set tests were conducted correcting for gene size, variant density and LD within and between genes. Tissue-set enrichment analyses were also performed using MAGMA implemented in FUMA, to test for enrichment of association signal in genes expressed in 54 tissue types from GTEx V8 (Bonferroni-corrected P-value threshold = 9.26 × 10−4)64,108.
