Ten individual SNPs (pair-wise r2>0.9 for all 10 SNPs based on hg19 1000 Genomes from the sample of African ancestry), located in an intergenic region on 3q26 (Chr 3, 166 471 942–166 489 551) were associated with fast beta EEG at P<5 × 10−8 (Table 2, Supplementary Table S2, Figures 1 and 2, Supplementary Figure S4). The most significant SNP was rs11720469 (P<4.5 × 10−9); the minor allele (G) was negatively associated with fast beta EEG (β: − 0.124; Supplementary Figure S5). Figure 2 graphically illustrates this GWAS signal, as well as the known genes located upstream and downstream of this signal, including BCHE, PDCD10, WDR49, SERPINI1, SERPINI2 and ZBBX. GABRA2 was also associated with fast beta EEG but not at a genome-wide level (P<0.01). GCTA estimated that 33.8% (s.e.: 0.014, P<5.5 × 10−17) of the variance in fast beta EEG was due to genome-wide SNPs (narrow sense heritability).
