The candidate gene-set analysis demonstrates a consistent relationship between schizophrenia and ASD. We observed strong genetic correlation between ASD and schizophrenia and a striking concordance in terms of direction of effect (binomial sign test of effect). Moreover, when examining only those genes within the schizophrenia GWS loci, we observed enrichment through gene-based and partitioned heritability analyses. We have excluded confounding due to known sample overlap.
