highly associated gene to emerge from their analysis was DYRK1A (P=8.7 × 10−5) on chromosome 21, which is a candidate gene for developmental disabilities.14 In this same study, attempts to replicate the associations between seven candidate genes or polymorphisms from the literature (DAT1, DRD2, DRD4, 5-HTTLPR, COMT, MAOA and C1QTNF7) and AAB as a categorical variable were unsuccessful. Likewise, studies in a community-based sample reported no significant associations between a closely related behavioral disinhibition phenotype and rare nonsynonymous exonic or common SNPs from across the genome.15, 16
