Additional screens of high-risk samples that are likely to be enriched for AAB are needed to detect genetic associations. Our goal in the present study was to fill this gap and examine the molecular genetic basis of AAB in such a sample. We examined SNP heritability of a dimensional measure of AAB, followed by a GWAS, gene-based tests and gene set enrichment tests. Participants were part of a case–control sample in which cases met the criteria for alcohol dependence. Alcohol-use disorders are phenotypically and genetically correlated with AAB and ASPD,17, 18 suggesting that this sample is likely to be enriched for variants contributing to AAB. We then examined whether genes of interest were expressed in human brain to evaluate the biological plausibility that identified genes would be associated with a behavioral outcome.
