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Chunk #0 — 1. Introduction

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Effects of chronic systemic treatment with peroxisome proliferator-activated receptor α activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide in adult mice.
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Peroxisome proliferator-activated receptor (PPAR) is a ligand-dependent transcription factor (Chinetti et al., 2000). Currently, three subtypes α, γ, and β/δ are identified. PPARs regulate lipid/glucose metabolism and adipocyte differentiation; therefore, PPARs have gained a great deal of attention as a potential therapeutic target for metabolic syndrome (Kersten et al., 2000).