Chunk #20 — Materials and Methods — Effects of systemic AM3506 treatment — Pre-extinction treatment with SR141716 before AM3506

Source

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.

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The purpose of this experiment was to test whether the extinction-facilitating effect of AM3506 was dependent on the action at CB1R. SR141716 (Rimonabant; 1.0 mg/kg) was administered 50 min before 0 or 1.0 mg/kg AM3506, and extinction training tested 60 min later. A control group of mice treated with vehicle instead of each drug was also included and tested in the same manner.