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Chunk #19 — Materials and Methods — Effects of systemic AM3506 treatment — Pre-extinction treatment in unconditioned mice

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Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.
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Here, there was no US presentation during conditioning. AM3506 was administered at a dose of 0 or 1.0 mg/kg 60 min before extinction training. The purpose was to test whether AM3506 produced nonspecific effects on unconditioned fear.