Chunk #15 — Materials and Methods — Statistical analyses: testing genome-wide SNP and indel associations with nicotine dependence

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Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.

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The sample-specific GWAS results were combined in METAL31 using inverse variance-weighted meta-analysis. The standard GWAS threshold (P<5 × 10−8) was used to declare statistically significant results. The I2 index was used to assess heterogeneity across samples.32