Aim 5 (rare variation) is a “cheap-seq” aim. We will conduct inexpensive (~$50/subject) schizophrenia-focused sequencing of 200 genes in 20,000 subjects. Genes will be selected based on all available sequencing results. For 200 genes, we will increase power far more cost-effectively than whole exome (10× cheaper) or whole genome sequencing (25× cheaper) in the same time frame. We propose an efficient and affordable way to markedly increase sample sizes for the most promising loci in a new sample of 20,000 subjects.
