A putatively novel finding comprises the 16p11.2 region (identified in the SNP and gene-based tests of association and in S-PrediXcan analysis). Deletions and duplications in this region have previously been reported to be associated with autism and schizophrenia38,39, while a common 16p11.2 inversion underlies susceptibility to asthma and obesity40. The inversion explains a substantial proportion of variability in expression of multiple genes in this region, including TUFM and SH2B140. Given the high LD in this region and high levels of co-expression of the differentially expressed genes, follow-up studies will be needed to determine which genes are functionally driving the association with cannabis use.
