Several of the top genes from the gene-based and/or S-PrediXcan analyses have previously shown an association with other traits, including schizophrenia (e.g., TUFM, NCAM1), BMI or obesity (e.g. SH2B1, APOBR, ATXN2L), alcohol use (e.g. ALDH2), intelligence and cognitive performance (CNNM2, CCDC101), and externalizing and impulsive phenotypes (e.g. CADM2; see Supplementary Table S3). Interesting is also the association with HTR1A; this gene has been implicated in alcohol and nicotine co-dependence41, BMI42, psychiatric disorders43,44, and antipsychotic pharmacological treatment response45. At the phenotypic level, associations between cannabis use and psychiatric disorders2 and use of other substances30 are well-established.
