RecessiveEarlier onset3.75E-06chr11:19526139In intron of NAV2Encodes neuron navigator 2, an retinoic acid-responsive gene that seems to play a role in neuronal development. It is highly expressed in fetal and adult brain. Lies within/close to linkage region for autism from primary studies and meta-analysis (Duvall et al. 2007; Szatmari et al. 2007b; Trikalinos et al. 2006). Gene is associated with bipolar disorder in GWAS at P values of 10−4 (Sklar et al. 2008)Also associated with ADHD at 10−4 in GWAS of Neale et al. (2008a)rs1335515 DominantEarlier onset7.76E-06chr14:57455118Intergenicrs4810685 DominantEarlier onset6.51E-06chr20:45834120In intron of SULF2Encodes heparan sulfatase 2. Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling, SULF2 can change properties of the coreceptors by removing sulfate moieties. The gene is essential for mammalian development and survival, it shows ubiquitous expression. Lies close to linkage region for autism (Allen-Brady et al. 2008)Site known for CNVsValues indicated in bold are SNPs that appear in the list more than once aWhere not indicated otherwise, the information is derived from the UCSC Browser, NCBI’s OMIM, Gene and Unigene databases, and the Sullivan Lab Evidence Project website (location of SNP expanded by ±5 Mb for genome-wide linkage scans,
