this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. It plays a role in the cell response to environmental stresses and is expressed in brain an multiple other tissues. Lies within suggestive linkage region for ADHD from meta-analysis (Zhou et al. 2008c) rs806276 DominantLater onset1.02E-07chr6:91264072rs9451437AdditiveLater onset3.08E-06chr6:91266607Within 15 kb of MAP3K7rs6968385RecessiveEarlier onset1.61E-06chr7:109834707IntergenicLies within linkage region for autism spectrum disorder (Trikalinos et al. 2006), and falls into CNV found in study on schizophrenia (Walsh et al. 2008)rs17658378AdditiveLater onset9.15E-06chr8:116463251 Within 30 kb upstream of TRPS1Encodes trichorhinophalangeal syndrome I, a zinc finger transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymusrs1325154 DominantLater onset4.75E-06chr9:12572565IntergenicFalls into linkage region for nicotine dependence (Li et al. 2008)Site known for CNVsrs874426 RecessiveEarlier onset3.75E-06chr11:19526139In intron of NAV2Encodes neuron navigator 2, an retinoic acid-responsive gene that seems to play a role in neuronal development. It is highly expressed in fetal and adult brain. Lies within/close to linkage region for autism from primary studies
