function, expressed in brain and other tissues. Potentially plays an important role in development. Finding lies within linkage region for schizophrenia from meta-analysis (Lewis et al. 2003)rs3892715DominantEarlier onset6.46E-06chr3:196239299Within 31 kb upstream of C3orf21Gene of unknown function, codes for membrane protein expressed in brain and other tissues rs9687070 AdditiveEarlier onset9.34E-06chr5:178501755In intron of ADAMTS2Encodes ADAM metallopeptidase with thrombospondin type 1 motif 2, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. May also play a role in development that is independent of its role in collagen biosynthesis. Expressed at high levels in skin, bone, tendon and aorta and at low levels in thymus and brain. Lies in suggestive linkage region for smoking (Duggirala et al. 1999) rs9687070 RecessiveEarlier onset2.98E-06chr5:178501755rs10039254AdditiveLater onset7.87E-06chr5:178503520rs3776816RecessiveEarlier onset4.64E-06chr5:178507474 rs806276 AdditiveLater onset3.38E-07chr6:91264072Within 20 kb upstream of MAP3K7Encodes mitogen-activated protein kinase kinase kinase 7. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. It plays a
