Odds ratios and 95% confidence intervals were calculated for each allele in unconditional logistic regression models while adjusting for age at cohort entry (quartiles), body mass index (BMI, kg/m2, quartiles), sex, and race/ethnicity (pooled analysis) in ethnic-stratified and pooled analyses. Associations with the two variants at KCNQ1 were examined adjusting for the other allele. Potential confounding factors including, smoking history, education, physical activity, and history of hypertension were evaluated but did not influence the results. Potential confounding by percent European ancestry was examined in a subset of African American men (336 cases, 397 controls) with available genetic ancestry information [16], [31], [32].
