When combining the 22 RCTs, our meta-analysis showed a significant success rate of disulfiram compared to controls: g = .58 (95%CI = .35–.82) (Figure 2). I2 was 72%. A visual inspection of the funnel plot revealed asymmetry, indicating a possible publication bias. The trim-and-fill analysis indicated that there were 4 potentially missing studies on the left side of the funnel plot. Nevertheless, the summary effect-size remained significant after correcting for the putatively missing studies [adjusted effect-size g = .47 (95%CI = .24–.71)]. The summary effect-size reached significance in all cases in the leave-one-out analysis, with summary effect-sizes varying from g = .53 to g = .63 (all p<.001). Meta-regression indicated a significant effect of publication year (β = .03, p<.001) and treatment duration (β = −.01, p<.001), but not of disulfiram dosage or risk of bias score.
