In summary, we present a gene-wide analysis of two GWAS studies, one of schizophrenia, one of bipolar disorder. We show that SNPs within genes are enriched for association signals. We show that the datasets contain substantially more gene-wide signals that surpass nominal significance thresholds than expected by chance, and also but less robustly, that there is an overlap in risk between schizophrenia and bipolar disorder. Genes surpassing thresholds at which there is a considerable enrichment for observed signals are likely to be highly enriched for true associations, and such genes and their family members may form the basis for gene-wide replication studies.
