DGKH was previously implicated in bipolar disorder at genome wide significance level, p=1.5×10−8 (18). Diacylglycerol kinases are central to an enormous range of signal transduction pathways of potential relevance to neuropsychiatric disorders18. While we did not observe evidence for DGKH, DGKI, encoding diacylglycerol kinase iota and one of only 8 family members represented in this analysis, gave gene-wide evidence for association at a level surpassing the p=0.001 threshold in schizophrenia (table S1; gene-wide pmin=6.7×10−4). Our identification of multiple genes closely related to the handful of genes that have been reported to date by GWAS studies of psychosis points further to the utility of gene-wide analysis of GWAS datasets.
