×10−4). Based upon a meta-analysis p value of 7×10−8 (19) CACNA1C can now be considered very likely to be a true positive. Interestingly, mutations in this gene are already known to cause Timothy Syndrome, a disorder whose features include autistic traits (see19). Thus, this gene, as well as the other genes whose products encode α1 subunits (which form the ion pore) of voltage-gated calcium channels, are candidate genes for neuropsychiatric disorders. It is of considerable interest that CACNA1B, encoding the subunit typical of the calcium channels which control neurotransmitter release from neurons and one of only 8 CACNA1 family members represented in our analysis, showed evidence for association (truncated at 0.001, p=0.002) in schizophrenia. This is at a level that just missed our threshold for inclusion in table S1, but is still in the range that is considerably enriched for observed signals compared with the null (p=0.0004). Thus, the calcium channelopathies postulated in bipolar disorder may also operate in schizophrenia.
