In addition to the data previously reported from the SNP based analysis of the present bipolar dataset, three genes have been reported that meet criteria for genome-wide significance in bipolar disorder; ANK3 (ankyrin 3, node of Ranvier (ankyrin G)), CACNA1C (calcium channel, voltage-dependent, L type, alpha 1C subunit)19 and DGKH (diacylglycerol kinase, eta)18. In the present study, we found support for one of these as well as in family members of two of them. CACNA1C was not identified as a gene of particular interest when the WTCCC bipolar SNP data were examined3 although those data did subsequently contribute to the meta-analysis19. In the present study, at the level of the gene, the best corrected SNP p value in the bipolar analysis was unimpressive (p=0.037) whereas the product-method successfully identified this gene as a potential candidate (table S2; gene-wide pmin =7 ×10−4). Based upon a meta-analysis p value of 7×10−8 (19) CACNA1C can now be considered very likely to be a true positive. Interestingly, mutations in this gene are already known to cause Timothy Syndrome, a disorder whose features include autistic
