A negative quadratic (i.e., inverted U-shaped) correlation between age and the node degree was found in the left pallidum (PAL) and left SPG (Figure 3A, blue regions). Similarly, linear age-related increases in the node efficiency were found in 5 brain regions, including the bilateral SMA, left IOG, right ORBmed, and right middle cingulate gyrus (MCG) (Figure 3B, red regions). Linear age-related decreases in the node efficiency were found in 4 brain regions, including the bilateral PCL, left SFGdor, and right SPG (Figure 3B, green regions). A positive quadratic developmental trajectory of node efficiency was observed in the right PCUN (Figure 3B, yellow regions). A negative quadratic correlation between age and the node efficiency was found in the left PAL and left SPG (Figure 3B, blue regions). Moreover, linear age-related increases in the node betweenness were found in 3 brain regions, including the left PCG, right ORBmed, and right SFGmed (Figure 3C, red regions). Linear age-related decreases in the node betweenness were found in 4 brain regions, including the bilateral PCL, right PCUN, and right calcarine cortex (CAL) (Figure 3C, green regions).
