The presence of linear and quadratic age-related changes in the summary regional nodal parameters was examined using a GLM analysis. We identified the brain regions showing significant age-related changes (p<0.05 or p<0.01, uncorrected) in the regional nodal parameters (Figure 3). Linear age-related increases in the node degree were found in 5 brain regions, including the bilateral supplementary motor area (SMA), left inferior occipital gyrus (IOG), right ORBmed, and right superior temporal pole (TPOsup) (Figure 3A, red regions). Linear age-related decreases in the node degree were found in 6 brain regions, including the bilateral paracentral lobule (PCL), left dorsal superior frontal gyrus (SFGdor), right superior parietal gyrus (SPG), right heschl gyrus (HES), and right hippocampus (HIP) (Figure 3A, green regions). A positive quadratic (i.e., U-shaped) developmental trajectory of the node degree was observed in the bilateral PCUN (Figure 3A, yellow regions). A negative quadratic (i.e., inverted U-shaped) correlation between age and the node degree was found in the left pallidum (PAL) and left SPG (Figure 3A, blue regions). Similarly, linear age-related increases in the node efficiency were found in 5 brain
