We analyzed the effects of age, sex, and age-by-sex interaction on the summary global network parameters (Table 1). Linear positive age-related changes (p<0.05) were found in the normalized clustering coefficient, small-worldness, and local efficiency. There was no significant age effect on the clustering coefficient, characteristic path length, normalized characteristic path length, and global efficiency. We also found significant sex differences (p<0.05) in 3 global network parameters in which the girls showed significantly higher values in the characteristic path length and normalized characteristic path length but significantly lower values in the global efficiency compared with the boys. There was no significant age-by-sex interaction in all global network parameters.
