At the regional level, we defined 21 global hubs as the brain regions with higher values (>mean + SD) in any of the regional nodal parameters across all subjects (Figure 2, see Table S2). In particular, 14 of the 21 global hubs (the bilateral anterior cingulate gyrus [ACG], bilateral superior temporal gyrus [STG], bilateral angular gyrus [ANG], bilateral postcentral gyrus [PoCG], bilateral insula [INS], left precuneus [PCUN], left medial superior frontal gyrus [SFGmed], right superior occipital gyrus [SOG], and right supramarginal gyrus [SMG]) were identified by all of the regional nodal parameters. Five global hubs (the bilateral rolandic operculum [ROL], left posterior cingulate gyrus [PCG], right SFGmed, and right PCUN) were identified by both the node degree and node efficiency. Two global hubs (the right middle frontal gyrus [MFG] and right medial orbitofrontal cortex [ORBmed]) were identified only by the node betweenness. These global hubs were mainly composed of recently evolved association and primitive paralimbic regions [51].
