Table 3 shows the results for SNPs in genes in the dopamine pathway. Only SNPs with a p-value less than 0.05 for craving are shown and only for this subset of SNPs were comparisons with DSM-IV alcohol dependence and dependence without craving made. Setting a liberal threshold of p < 0.05, SNPs in DRD2, DRD3 and SNCA showed evidence for association with craving. Comparing the results for these SNPs with those for DSM-IV alcohol dependence, SNPs in DRD3 and SNCA appeared to have independent genetic effects on craving, infrequently showing a p-value < 0.05 for alcohol dependence while for DRD2, a number of SNPs associated with craving had a p-value < 0.05 for alcohol dependence. With some exception, the SNPs associated with craving did not show p-values < 0.05 for dependence without craving.
