Figure 2 and Table 4 summarize the results of the autosomal genomewide analysis using the craving for alcohol phenotype. The best association for craving was found for SNP rs2454908 (p-value=1.83 × 10−6) on chromosome 16. Table 4 also compares results for craving with those for DSM-IV alcohol dependence and with dependence without craving. For rs2454908, the odds-ratio and p-value for craving and DSM-IV dependence were comparable; however, the p-value for this SNP was 0.018 when examining dependence without craving. Of the 30 most significant SNPs for craving, 20 SNPs also had p-values less than 0.05 for DSM-IV alcohol dependence with or without craving, but only rs2454908 had a p-value less than 0.05 for dependence without craving. The overlap between alcohol dependence and craving dropped steadily as the threshold for association with craving was made less stringent (Figure 3).
