Chunk #65 — STAR★METHODS — QUANTIFICATION AND STATISTICAL ANALYSIS — Expression-based mapping of SNPs — TWAS

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Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.

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Colocalization of overlapping GWAS and gene expression associations was assessed using coloc50 as implemented by FUSION. coloc is a Bayesian method that estimates the posterior probability that associations within a locus for two outcomes are driven by a shared causal variant (PP4).