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Chunk #22 — Discussion — Evidence for the hippocampal coupling account

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The hippocampus is coupled with the default network during memory retrieval but not during memory encoding.
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Based on the fact that fMRI coherence studies [6], [8] have strongly linked HF to the DMN, it has been proposed that the DMN is actually a hippocampal memory network mediating episodic memory and other internally-oriented operations [6], [18], [26] including thinking about the future [27], self-referential processing [29], and mental imagery [30]. Recently, Hassabis and Maguire proposed that these operations all involve the common process of “scene construction”, defined as the process of mentally generating and maintaining a complex and coherent scene or event [41]. They further showed that conditions requiring scene construction without episodic memory content, such as mental imagery of fictitious events, also activate HF [30]. Moreover, patients with HF damage show pronounced deficits in mental imagery of complex fictitious scenes [42]. Animal studies also link HF to the DMN. These studies have not only shown strong connections between HF and components of the DMN at the neuroanatomical level [43], [44], but also at the neurofunctional level [45], [46]. Yet, despite these findings linking HF to the DMN, the current results clearly show that, at least during