RNA-seq data see Rao et al.14. Briefly, RNA was extracted via the Qiagen RNeasy kit. RNA was sequenced on the Illumina HiSeq 2000, which resulted in an average of 91,252,228 million paired-end reads (s.d. = 33,916,588).Table 1RNA-seq data used in the study.Descriptive information on RNA-seq samplesHumanPrimateData sourcePRJNA530758; PRJNA551775; PRJNA551908; PRJNA551909GSE96731; GSE144783GSE96732n5653Traits53.57% AUD16.98% Very high drinkers, 20.75% high drinkers13.2% Binge drinkers, 33.96% low drinkers and 15.09% NaïveBrain regionssPFC, NAc, BLA and CEAPFC (Area 32), NAc core and CEAAgeM = 57.34 (s.d. = 8.91)4–11 yearsSex76.79%100% MaleBrain pH6.60 (s.d. = 0.25)NAPMIM = 32.81 (s.d. = 13.75)< 1 hCigarette smoker67.86%0%Primate samples lacked information on brain pH AUD includes both DSM-IV diagnoses of alcohol abuse (two thirds of AUD cases) and alcohol dependence (one third of AUD cases). PMI stands for post-mortem interval or the # of hours since death until brain tissue was frozen or processed.
