We performed fine mapping for TWAS using FOCUS36, a method that estimates credible gene sets predicted to include the causal gene, which can be prioritized for functional assays. We detected 53 credible sets at a nominal confidence level (set at 90% PIP). These contained 145 gene–tissue associations with an average PIP of 32% (Supplementary Table 13). For the 19 gene–tissue associations having PIP >90%, 9 are from brain tissues (for example, ZNF184 expression in the hypothalamus (PIP of 0.94%), MTCH2 expression in the nucleus accumbens (basal ganglia) (PIP of 99%), SLC4A8 expression in the dorsolateral prefrontal cortex (PIP of 98%), YPEL3 expression in the cerebellum (PIP of 100%) and CHD9 expression in the dorsolateral prefrontal cortex (PIP of 100%).
