We examined overlapped genes by both gene-based association analysis and TWAS in brain tissues and/or H-MAGMA analysis using Hi-C brain annotations. Among the 130 genes associated with PAU in EUR, 62 were also implicated by TWAS findings either by single brain tissue (S-PrediXcan) or across brain tissues (S-MultiXcan), 82 have evidence of brain chromatin interaction and 51 have evidence from both TWAS and Hi-C annotations including ADH1B, DRD2, KLB and others (Supplementary Table 9).
