We used Hi-C-coupled MAGMA (H-MAGMA)35 to implicate risk genes associated with PAU by incorporating brain chromatin interaction profiles. A total of 1,030 gene–chromatin associations were identified in six brain Hi-C annotations, representing 401 unique genes (Supplementary Table 12). Fifty-eight genes showed association with chromatin interaction in all six annotations, including ADH1B, ADH1C, DRD2, EVI2A and others that also showed evidence by TWAS in brain tissues.
