Among 4,491 substance-naïve children aged 9–10 years who completed the baseline session of the ABCD Study®31, the addiction-rf PRS was positively correlated (after Bonferroni correction) with BAS fun-seeking (an aspect of externalizing behavior; p=2.09e-05), family history of drug addiction (p=7.04e-07), family history of hospitalization due to mental health concerns (including suicidal behavior; p=4.64e-06), childhood externalizing behaviors (e.g., antisocial; p=1.62e-05), childhood thought problems (p=3.51e-06), sleep duration (p=1.52e-07), parental externalizing and substance use behaviors (e.g., prenatal tobacco exposure; p=2.87e-11), maternal pregnancy characteristics (e.g., urinary tract infection during pregnancy, p=2.70e-7), socio-economic disadvantage (e.g., child’s neighborhood deprivation; p= 9.84e-07), and child’s likeliness to play sports (p=2.80e-06) (Supplemental Figure 10; Supplemental Table 21 for results from all phenotypes and Supplementary Table 23 for measure inclusion criteria).
