In the BioVU sample (EUR N=66,914)30, the addiction-rf PRS was associated with SUDs (p=3.31e-29; Supplemental Figure 8), various types of substance involvement [e.g., Tobacco Use Disorder p=9.79e-24, alcoholism (so named in EHR, we note the term “alcohol use disorder” is more appropriate), p=1.12e-21), chronic airway obstruction (p=4.99e-10)], and several psychiatric disorders, with the strongest being bipolar disorder (p=2.44e-11). Controlling for any SUD diagnosis to account for causal effects found similar associations with alcoholism, mood disorders, respiratory disease, and heart disease (Supplemental Figure 9A). Controlling for tobacco dependence diagnosis did not significantly modify associations (Supplemental Figure 9B).
